I definitely think that despite the fact that Ginny and Harry "broke up" in the last book, that they will encounter some major struggles in the seventh book that will require them to be drawn closer together. I also think that Ron and Hermione will finally see that they are meant to be together. There are obviously definite signs about that in the books, and Rowling herself does not deny them.
I think some main characters will die, namely Draco and possibly Neville? I don't know for sure, and I haven't really thought about that as much as I should.... in any case, it wouldn't surprise me if many of the main characters died in an all-out battle between good and evil (similar to what happened in the last two books).
~Tiffany